Women's Health Issues
Volume 16, Issue 6 , Pages 346-352 , November 2006

Associations between fracture incidence and use of depot medroxyprogesterone acetate and anti-epileptic drugs in women with developmental disabilities

  • Kathleen C. Watson, RN, PhD

      Affiliations

    • Biobehavioral Nursing and Health Systems, School of Nursing, Seattle, Washington
    • Center on Human Development and Disability, University of Washington, Seattle, Washington
    • Corresponding Author InformationCorrespondence to: Kathleen C. Watson, RN, PhD, Department of Biobehavioral Nursing and Health Systems, Center on Human Development and Disability, University of Washington, Box 357266, Seattle, WA 98195-7266.
    • ,
  • Martha J. Lentz, RN, PhD

      Affiliations

    • Biobehavioral Nursing and Health Systems, School of Nursing, Seattle, Washington
    • Office for Nursing Research, School of Nursing, University of Washington, Seattle, Washington
    • ,
  • Kevin C. Cain, PhD

      Affiliations

    • Office for Nursing Research, School of Nursing, University of Washington, Seattle, Washington
    • Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, Washington

Received 20 October 2005 ,Revised 26 September 2006 ,Accepted 26 September 2006.

References 

  1. American Academy of Pediatrics, Committee on Drugs. Medroxyprogesterone acetate (Depo-Provera). Pediatrics. 1980;65:648
  2. Amesse LS, Boyce C, Pfaff-Amesse T. Menstrual control in the developmentally delayed adolescent: New treatment options. Journal of Pediatric Adolescent Gynecology. 2006;19:237–241
  3. Angelopoulo N, Souftas V, Sakadamis A, Mandroukas K. Bone mineral density in adults with Down’s syndrome. European Radiology. 1999;9:648–651
  4. Aspray TJ, Francis RM, Thompson A, Quilliam SJ, Rawlings DJ, Tyrer SP. Comparison of ultrasound measurements at the heel between adults with mental retardation and control subjects. Bone. 1998;22:665–668
  5. Berenson AB, Radecki CM, Grady JJ, Rickert VI, Thomas A. A prospective, controlled study of the effects of hormonal contraception on bone mineral density. Obstetrics and Gynecology. 2001;98:576–582
  6. Bischof F, Basu D, Pettifor MB. Pathological long-bone fractures in residents with cerebral palsy in a long-term care facility in South Africa. Developmental Medicine & Child Neurology. 2002;44:119–122
  7. Carr EG, Smith CE, Giacin TA, Whelan BM, Pancari J. Menstrual discomfort as a biological setting event for severe problem behavior: Assessment and intervention. American Journal on Mental Retardation. 2003;108(2):117–133
  8. Center J, Beange H, McElduff A. People with mental retardation have an increased prevalence of osteoporosis: A population study. American Journal on Mental Retardation. 1998;103:19–28
  9. Chamberlain A, Rauh J, Passer A, McGrath M, Burket R. Issues in fertility control for mentally retarded female adolescents: I (Sexual activity, sexual abuse, and contraception). Pediatrics. 1984;73:445–450
  10. Clark MK, Sowers MR, Nichols S, Levy B. Bone mineral density changes over two years in first-time users of DMPA. Fertility and Sterility. 2004;82:1580–1586
  11. Cromer BA, Scholes D, Berenson A, Cundy T, Clark MK, Kaunitz AM, et al. Depot medroxyprogesterone acetate and bone mineral density in adolescents—The Black Box warning: A Position Paper of the Society for Adolescent Medicine. Journal of Adolescent Health. 2006;39:296–301
  12. Curtis R, Freitag P, LaGuardia JJ, Thornton S, Vicari S, Markwell S. Spinal cord compromise: An important but underdiagnosed condition in people with mental retardation. Public Health Reports. 2004;119:396–400
  13. Dizon CD, Allen LM, Ornstein MP. Menstrual and contraceptive issues among young women with developmental delay: A retrospective review of cases at the Hospital for Sick Children, Toronto. Journal of Pediatric Adolescent Gynecology. 2005;18:157–162
  14. Frederiksen MC. DMPA contraception in women with medical problems. Journal of Reproductive Medicine. 1996;41(5 Suppl):414–418
  15. Glick NR, Fischer MH, Heisey DM, Leverson GE, Mann DC. Epidemiology of fractures in people with severe and profound developmental disabilities. Osteoporosis International. 2004;16:389–396
  16. Grover SR. Menstrual and contraceptive management in women with an intellectual disability. Medical Journal of Australia. 2002;176:108–110
  17. Hseih K, Heller T, Miller AB. Risk factors for injuries and falls among adults with developmental disabilities. Journal of Intellectual Disabilities Research. 2001;45:76–82
  18. Huovinen KJ. Gynecological problems of mentally retarded women. Acta Obstetricia et Gynecologica Scandinavica. 1993;72:475–480
  19. Jaffe JS, Timell AM, Elolia R, Thatcher SS. Risk factors for low bone mineral density in individuals residing in a facility for the people with intellectual disability. Journal of Intellectual Disability Research. 2005;49:457–462
  20. Jaffe JS, Timell AM, Gulanski BI. Prevalence of low bone density in women with developmental disabilities. Journal of Clinical Densitometry. 2001;4:25–29
  21. Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A. The burden of osteoporotic fractures: A method for setting intervention thresholds. Osteoporosis International. 2001;12:417–427
  22. Lappe JM, Stegman MR, Recker RR. The impact of lifestyle factors on stress fractures in female army recruits. Osteoporosis International. 2001;12:35–42
  23. Lohiya G-S, Crinella FM, Tan-Figueroa L, Caires S, Lohiya S. Fracture epidemiology and control in a developmental center. Western Journal of Medicine. 1999;170:203–209
  24. Lohiya G-S, Tan-Figueroa L, Iannucci A. Identification of low bone mass in a developmental center: Finger bone mineral density measurement in 562 residents. Journal of the American Medical Directors Association. 2004;November–December:371–376
  25. Melton LJ, Crowson SS, O’Fallon WM. Fracture incidence in Olmsted County, Minnesota: Comparison of urban with rural rates and changes in urban rates over time. Osteoporosis International. 1999;9:29–37
  26. Molsa PK. Inducement of therapeutic amenorrhea in mentally retarded women: Two-year follow-up study. American Journal of Mental Deficiency. 1986;90:591–593
  27. Ott SM, Scholes D, LaCroix AZ, Ichikawa LE, Yoshida CK, Barlow WE. Effects of contraceptive use on bone biochemical markers in young women. Journal of Clinical Endocrinology & Metabolism. 2001;86:179–185
  28. Peabody TD, Stasikelis PJ. Fractures in adults at an institution for the developmentally disabled. Clinical Orthopaedics and Related Research. 1999;366:217–220
  29. Penovich PE, Eck KE, Economou VV. Recommendations for the care of women with epilepsy. Cleveland Clinic Journal of Medicine. 2004;71:S49–S57
  30. Quint EH, Elkins TE, Sorg CA, Kope S. The treatment of cyclic behavior changes in women with mental disabilities. Journal of Pediatric and Adolescent Gynecology. 1999;12:139–142
  31. Ray JG, Papaioannou A, Ioannidis G, Adachi JD. Anticonvulsant drug use and low bone mass in adults with neurodevelopmental disorders. Quarterly Journal of Medicine. 2002;95:219–223
  32. Scholes D, LaCroix AZ, Ichikawa LE, Barlow WE, Ott SM. Injectable hormone contraception and bone density: Results from a prospective study. Epidemiology. 2002;13:581–587
  33. Scholes D, LaCroix AZ, Ichikawa LE, Barlow WE, Ott SM. Change in bone mineral density among adolescent women using and discontinuing DMPA contraception. Archives of Pediatric and Adolescent Medicine. 2005;159:139–144
  34. Scholes D, LaCroix AZ, Ott SM, Ichikawa LE, Barlow WE. Bone mineral density in women using DMPA for contraception. Obstetrics & Gynecology. 1999;93:233–238
  35. Servais L, Jacques D, Leach R, Conod L, Hoyois P, Dan B, et al. Contraception of women with intellectual disability: Prevalence and determinants. Journal of Intellectual Disability Research. 2002;46:108–119
  36. Tannenbaum TN, Lipworth L, Baker S. Risk of fractures in an intermediate care facility for persons with mental retardation. American Journal on Mental Retardation. 1989;93:444–451
  37. Taylor DV, Rush D, Hetrick WP, Sandman CA. Self-injurious behavior within the menstrual cycle of women with mental retardation. American Journal on Mental Retardation. 1993;97(6):659–664
  38. Tyler CV, Snyder CW, Zyzanski S. Screening for osteoporosis in community-dwelling adults with mental retardation. Mental Retardation. 2000;38:316–321
  39. US Department of Health and Human Services. (2004). Bone health and osteoporosis: A report of the surgeon general. Rockville, MD: U.S. Department of Health and Human Services, Office of the Surgeon General. Available: www.surgeongeneral.gov/library. Accessed October 18, 2005.
  40. Wingfield M, McClure N, Mamers PM, Weigall DT, Paterson PJ, Healy DL. Endometrial ablation: An option for the management of menstrual problems in the intellectually disabled. The Medical Journal of Australia. 1994;160:533–536

 Support for this study was provided by NINR NIH 5 T32 NR07106-07 and by NINR NIH P30 NR04001.

PII: S1049-3867(06)00112-5

doi: 10.1016/j.whi.2006.09.003

Women's Health Issues
Volume 16, Issue 6 , Pages 346-352 , November 2006

Article Tools